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Agaricus blazei Murill

Mushroom with Miracle Properties

 

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Agaricus blazei Muril - Mushroom

Agaricus blazei Muril

Agaricus blazei murill mushrooms are unique organisms, stationary like a plant, yet built from chitin (ki -tin) like the shell of a lobster. Understanding the properties of chitin is the key to understanding how to choose an effective, high quality medicinal mushroom product.

Chitin is indigestible by humans, yet the chitin, which makes up the cell walls of mushrooms, contains the potent immune building compounds common to all medicinal mushrooms, the polysaccharides. Indisputably, only heat can break down the indigestible chitin and release the active compounds into a concentrated, bio-available form. Therefore Agaricus blazei Murill mushrooms are always prepared with heat and water, as a tea or a decoction and never used in the un-extracted form (as dried mushroom powder or dried mycelium powder), and never prepared as a tincture (soaked in alcohol alone in the absence of heat).

Scientists have also recognized the importance of heat. It is no coincidence that every significant scientific study on the use of Agaricus blazei Murill mushrooms for immune health has been conducted with a heat-based extract, thats what Asians researchers developed in long years studies.Therefore we offer dehydrates hot water extracts where the heat releases the polysaccharides from the chitinous cell walls of the mushroom and mushroom mycelium.

1000 ml of extract includes 2,2 lbs of Agaricus blazei Murill. If you would now prepare dried Agaricus blazei Murill in form of tea. you would drink at least 35 liters of water for the same amount of used dried mushrooms. This means you get a easy to take strong Agaricus blazei Murill product from Brazil. To preservate and sterilizate are used the most natural technologies.


  Agaricus blazei Muril - Mushroom   This means for that people who don't have the possibilities to prepare every day fresh the Agaricus blazei Murill tea or don't want to take so much liquid, the Liquid Hot Water Extract is the most natural strong alternative.

 



Research with Agaricus blazei Muril
J Nutr 2001 May;131(5):1409-13


Isolation of an antitumor compound
from Agaricus blazei Murill
and its mechanism of action.


Takaku T, Kimura Y, Okuda H.
Second Department of Medical Biochemistry and Central Research Laboratory,
School of Medicine, Ehime University,
Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.


The Basidiomycete fungus Agaricus blazei Murill has traditionally been used as a health food for the prevention of cancer, diabetes, hyperlipidemia, arteriosclerosis and chronic hepatitis.

In the present study, we examined the antitumor activities of various substances isolated from the lipid fraction of A. blazei. Tumor growth was retarded by the oral administration of the lipid fraction extracted from A. blazei with a chloroform/methanol mixture in sarcoma 180-bearing mice.

The substance with the antitumor activity in the lipid fraction was isolated via silica gel column chromatography, eluted with an acetonitrile/methanol (3:2) mixture and identified as ergosterol by direct comparison of the (1)H NMR and mass spectrometry spectral data of an authentic sample.

The oral administration of ergosterol to sarcoma 180-bearing mice significantly reduced tumor growth at doses of 400 and 800 mg/kg administered for 20 d without side effects, such as the decreases in body, epididymal adipose tissue, thymus, and spleen weights and leukocyte numbers induced by cancer chemotherapy drugs.

Ergosterol had no cytotoxicity against tumor cells. To clarify the antitumor activity of ergosterol, we examined the effects of ergosterol on tumor-induced angiogenesis using two in vivo models. Intraperitoneal administration of ergosterol at doses of 5, 10 and 20 mg/kg for 5 consecutive d inhibited the neovascularization induced by Lewis lung carcinoma cell-packed chambers, suggesting that either ergosterol or its metabolites may be involved in the inhibition of tumor-induced neovascularization.

Therefore, we further examined the inhibitory effects of ergosterol on Matrigel-induced neovascularization. Female C57BL/6 mice were subcutaneously inoculated with Matrigel containing acidic fibroblast growth factor and heparin with or without ergosterol. Ergosterol inhibited the Matrigel-induced neovascularization, suggesting that ergosterol directly inhibits Matrigel-induced neovascularization.

From these results, it seems likely that the antitumor activity of ergosterol might be due to direct inhibition of angiogenesis induced by solid tumors. This is the first report of ergosterol as an antiangiogenic substance.


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Revised-7/29/03